Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Novartis Pharmaceuticals
Age
50–75
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Male and female patients age 50 to 75 years of age inclusive, and in good health as determined by past medical history, physical examination, vital signs, electrocardiogram, and laboratory tests at screening
Patients diagnosed with primary osteoarthritis of the knee assessed locally for whom a total knee replacement is planned
General health status acceptable for total knee replacement surgery in the opinion of the investigator
Stable medications within 3 months prior to enrollment (such as appropriate pain medication, antibiotics prophylaxis) and standard of care
You may not be if
Presence of inflammatory arthropathy (including but not limited to rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, gout), active acute or chronic infection, or systemic cartilage disorder
Prior cartilage repair surgery, e.g. microfracture, autologous cartilage implantation (ACI) or else, at the same knee
Any surgical therapy or local treatment i.a. into the knee (viscosupplementation) to the knee within 2 months prior to enrollment
BMI \> 40; presence of uncontrolled diabetes or hyperthyroidism
Large effusion in the knee to be replaced, more than (\>)1 cm fluid in the suprapatellar space at the midline
Corticosteroid use by any route except topical and nasal in the 3 months prior to enrollment
History of malignancy of any organ system (other than localized basal cell carcinoma of the skin or in-situ cervical cancer), treated or untreated, within the past 5 years, regardless of whether there is evidence of local recurrence or metastases
Pregnant or nursing (lactating) women
Women of child-bearing potential, defined as all women physiologically capable of becoming pregnant
