Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Jon Rittenberger, MD
With
American Heart Association
Amantadine has been used to help patients awaken following traumatic brain injury, but it has not been studied in patients with anoxic brain injury.
Amantadine is a dopamine agonist and may help with stimulating the brain to awaken. The investigators will randomize subjects who remain comatose 72 hours following resuscitation from cardiac arrest to either amantadine or placebo. They will be treated with either amantadine or placebo for 7 days.
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Non traumatic cardiac arrest
Age 18 and older
Defibrillation and/or chest compressions by healthcare providers
Return of spontaneous circulation
You may not be if
Written do not attempt resuscitation (DNAR) reported to providers before randomization
Known prisoner or pregnancy
Lack of motor response to pain and absent N20 response on somatosensory evoked potentials prior to randomization
Initial CT demonstrating brain edema (defined as grey white ratio \<1.2)
Presence of malignant pattern on EEG at time of randomization
Next of kin unwilling to provide supportive care for at least one week after enrollment
Presently using other dopaminergic agent
Clareo Health | Amantadine to Speed Awakening After Cardiac Arrest
