Pharmacokinetic Interaction Study of Dapoxetine 30mg and Mirodenafil 50mg

Exclusion Criteria

• •Subject has a history such as liver diseases, kidneys, digestive system, respiratory system, endocrine system, nervous psychiatric, blood, cancer, cardiovascular diseases
• •Subject with clinically significant vital signs (sitting position blood pressure) (90 mmHg \> systolic blood pressure ≥ 140 mmHg, 60 mmHg \> diastolic blood pressure ≥ 90 mmHg)
• •History of drug abuse
• •History of caffeine, alcohol, smoking abuse
• •* caffeine(coffee,tea,coke)\> 4cups/day
• •* smoking \> 10 cigarettes/day
• •* alcohol \> 140g/week
• •Consumption of any grapefruit or grapefruit-containing juices over 1 cup a day
• •Previously donate whole blood within 60 days or component blood within 30 days
• •Subject has taken drugs which affects the ADME of investigational products
• •Subject with known for hypersensitivity reactions to mirodenafil/ dapoxetine or other drugs
• •Inadequate laboratory test result:
• •* AST(SGOT) or ALT(SGPT) or total bilirubin \> 1.5 x upper limit of normal range
• •* eGFR \< lower limit of normal range
• •Subject considered as unsuitable based on medical judgement by investigators