Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Further study details as provided by oncology center of Daping hospital
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Pathology or cytology was diagnosed with non-small cell lung cancer, and bone metastases was confirmed by CT or MRI , and the patients have to need intervention treatment.
VAS score\>2 points.
No paraplegia,
No pathological fractures of bone related events which require surgical intervention,
No major organ dysfunction,laboratory indexes meet the following requirements: Haemamoeba \>4.0 x 10\^9/L, Neutrophile granulocyte \> 2 x 10\^9/L, the platelet count\>100 x 10\^9/L, hemoglobin\>100 g/L; Liver result: the serum bilirubin is lower than normal ceiling; ALT and AST is lower than the maximum normal 1.5 times; Cr\<265 umol/l or 3.0 mg/dl, creatinine clearance\>60 ml/min.
You may not be if
The patients who have allergy of Bisphosphonates and zoledronate.
The patients who receive Molecular targeted therapy and chemotherapy within one month，The patients who receive Calcitonin and Aminoglycoside therapy in one week.
The patients who receive Pamidronic Acid in 28 days，The patients original sites receive radiotherapy before.
The patients who have history of thyroid surgery，receive tooth extraction in 2 weeks，and have been suffered from Bone Fracture and paraplegia.
The patients who have Serious internal medicine diseases and acute infection.
The patients With a history of psychiatric
Pregnancy or breast-feeding women, men have fertility requirements
Patients within clinical trials or not more than 30 days
Clareo Health | Zoledronic Acid Combined Radiotherapy for Bone Metastasis of Non-small Cell Lung Cancer
