Prediction of Clinical Response to SSRI Treatment in Bipolar Disorder Using Serotonin 1A Receptor PET Imaging

Exclusion Criteria

• •Diagnosis of any other major psychiatric disorders such as lifetime schizophrenia, schizoaffective disorder, current psychotic depression or current drug or alcohol abuse (within two months before the study) or recent drug or alcohol dependence (within six months before the study); anorexia nervosa or bulimia nervosa within the last year; IV drug use of ecstasy use more than three times. Meet criteria for a manic episode at the time of screening.
• •Previous failed trial of fluoxetine and citalopram by themselves or in combination with an anti-manic agent, defined as at least six weeks of treatment at the dose of 20 mg per day or more. Failure of two trials of any SSRI or SNRI antidepressant medications.
• •If the patients are discontinuing medications as part of the washout period or are starting valproate, previous failed trial of mood stabilizer that they will take alone.
• •Experienced intolerable side effects of both citalopram and fluoxetine in the past. If the subject is not on medications, intolerable side effects of valproate in the past.
• •History of clinical deterioration when any of the medications that the patient is taking at presentation have been discontinued in the past with the exception of any medications that will be continued during the research protocol.
• •A first-degree family history of schizophrenia if the subject is less than 33 years old
• •Significant active physical illness, including blood dyscrasias, lymphomas, hypersplenism, endocrinopathies, renal failure, chronic obstructive lung disease, autonomic neuropathies, peripheral vascular disease, malignancy
• •Actively suicidal, as defined by expressing ideation with a plan for suicide or develops suicidal ideation that requires immediate medication or treatment intervention.
• •Pregnancy, abortion or miscarriage in the two months prior to enrollment or plans to conceive during the course of study participation
• •Lactating women
• •ECT within the past 6 months
• •Subjects who endorse a history of prior head trauma and score 1.5 standard deviations below the mean on Trail-making A \& B will be excluded from study participation.
• •Metal implants, pacemaker, metal prostheses, metal orthodontic appliances or shrapnel in the body
• •Current, past or anticipated exposure to radiation, including:
• •* Having been badged for radiation exposure in the workplace
• •* Participation in nuclear medicine protocols in the last year. Subjects will be eligible, however, if the injected dose and dosimetry of the radiotracer are known and the cumulative annual exposure of the previous study and this study is lower than the annual limit for research subjects defined by the FDA (21 CFR 361.1)
• •History of claustrophobia that would prevent the participation in imaging scans
• •Current anticoagulant or anti-platelet treatment other than aspirin
• •Obesity with weight \>350 lbs or inability to fit into the MRI scanner