Safety and Efficacy of Bevacizumab in Combination With Carboplatin and Paclitaxel for Metastatic, Recurrent or Persistent Cervical Cancer

Exclusion Criteria

• •Pregnant or lactating
• •History of other malignancy within 5 years before screening, except for non-melanoma skin carcinoma
• •Ongoing disease involving the bladder or rectum at screening/baseline. In participants with pelvic disease, absence of tumor in the bladder or rectal mucosa must be demonstrated by magnetic resonance imaging (MRI) (preferred method, or endoscopy/cystoscopy if MRI is not easily accessible) within 28 days before enrolment
• •Evidence of abdominal free air
• •Bilateral hydronephrosis
• •Untreated central nervous system (CNS) metastases
• •Prior chemotherapy for recurrent, persistent or metastatic cervical cancer. Prior adjuvant or neoadjuvant chemotherapy for Stage I-IVA disease (i.e. for non-metastatic disease) is permitted if completed greater than (\>) 6 months before first study dose
• •Prior chemoradiation within the 3 months preceding first study dose
• •Prior radiotherapy delivered using cobalt
• •Prior or current bevacizumab or other anti-angiogenic treatment
• •Requirement for treatment with any medicinal product that contraindicates the use of any of the study drugs, may interfere with the planned treatment, affects participant compliance or puts the participant at high risk for treatment-related complications
• •Treatment with another investigational agent within 28 days or 2 investigational agent half-lives before first study dose
• •Major surgical procedure, open biopsy or significant traumatic injury within 28 days before the first dose of bevacizumab or anticipation of the need for major surgery during the course of study treatment
• •Minor surgical procedure within 2 days before the first dose of study drug
• •Any prior history of fistula or GI perforation
• •Known hypersensitivity to bevacizumab or any of its excipients, Chinese hamster ovary cell products or other recombinant human or humanized antibodies to any planned chemotherapy
• •Active GI bleeding or ulcer
• •Uncontrolled hypertension
• •Clinically significant active cardiovascular disease
• •National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) Version 4.0, Grade greater than or equal to (\>=) 2 peripheral vascular disease