Macronutrient Effects on Alzheimer's Disease (MEAL-2)

Exclusion Criteria

• •1. Diabetes not controlled by diet or exercise; current or previous use of diabetes medications
• •2. Average systolic blood pressure on three occasions \<90 or \>139 mm/Hg, diastolic blood pressure \<60, or current use of anti-hypertensive medications;
• •3. Clinically significant elevations in liver function tests as follows: SGOT \> 1.5 X ULN, SGPT \> 1.5 X ULN, Alkaline Phosphate \> 1.5 ULN.
• •4. Clinically significant elevations in lipid profile as follows: LDL\>190, triglycerides\>340, or total cholesterol\>260 and LDL/HDL ratio \>3.0.
• •5. Significant neurologic disease that might affect cognition, including AD (MCI will be allowed), stroke, Parkinson's disease, multiple sclerosis, or severe head injury with loss of consciousness \> 30 minutes or with permanent neurologic sequelae;
• •6. Significant medical illness or organ failure, such as uncontrolled hypertension or cardiovascular disease, chronic obstructive pulmonary disease, liver disease, or kidney disease;
• •7. Current use of antipsychotic, anti-depressant, anti-convulsant, anticoagulant, anxiolytic, or sedative medications;
• •8. Current use of cognition-enhancing medications;
• •9. Current use of glucocorticoids;
• •10. Current use of cholesterol-lowering medications, including:
• •1. HMG-CoA Reductase Inhibitors \[Statins: Atorvastatin (Lipitor), Fluvastatin (Lescol or Lescol EX), Lovastatin, Pravastatin (Pravachol), Rosuvastatin (Crestor), Simvastatin (Zocor)\]
• •2. Bile Acid Resins \[Cholestyramine (Questran), Colestipol, Colesevelam (Welchol)\]
• •3. Fibric Acids Derivatives \[Fenofibrate (Tricor), Gemfibrozil\]
• •4. Combinations \[Amlodipine/Atorvastatin, Niacin/Lovastatin (Advicor), Ezetimibe/Simvastatin (Vytorin)\]
• •5. Miscellaneous Categories \[Ezetimibe (Zetia), Niacin aka Nicotinic acid (Niaspan)
• •6. Over-the-counter \[Red yeast rice, Niacinamide, Omega 3 fatty acids (fish or flax seed), Slo-Niacin\]
• •11. Common allergies/sensitivities to the following food products: dairy, wheat, gluten, tree nuts or peanuts, eggs, corn, seafood and soy. Other food sensitivities will be assessed on a case-by-case basis.
• •12. BMI ≤ 18.5
• •13. Current weight \<110 pounds
• •14. Clinically significant iron deficiency: Hemoglobin \<13.5 for white males, \<12.2 for white females, \<12.5 for black males, and \<11.5 for black females.
• •15. If female, menstruation in the past 12 months or hysterectomy and current hormone replacement therapy medication.
• •16. Major digestive disorders, absorption issues, or surgeries, including bowel resection, inflammatory bowel diseases (Ulcerative colitis or Crohn's disease), or irritable bowel syndrome (IBS) with a tendency toward diarrhea