Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
VA Office of Research and Development
Age
21–65
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Male or female veterans and civilians, 21-65 years old
Current major depressive disorder without psychotic features by DSM-5 (antidepressant regimens can be allowed and changed during the trial)
Montgomery-Asberg Depression Rating Scale (MADRS) 20 or higher
A minimum of 4 of 11 current alcohol use disorder symptoms by DSM-5
Heavy drinking at least 4 times in the past month ('heavy drinking' defined as 5 standard drinks per day for men and 4 standard drinks per day for women
Able to provide written informed consent
You may not be if
Current substance use disorder by DSM-5 in the past 3 months (except alcohol, tobacco, or cannabis)
Current or past history of psychotic features or psychotic disorder
Current dementia
Current uncontrolled hypertension (systolic BP \> 170 mm Hg or diastolic BP \> 100 mm Hg)
Unstable medical condition or allergy to ketamine, midazolam, naltrexone, or lorazepam---clinically determined by a physician
Imminent suicidal or homicidal risk
Pregnant or nursing women, positive pregnancy test, or inadequate birth control methods in women of childbearing potential
Positive opioid or illicit drug screen test (except marijuana)
Opioid use within 10 days prior to study medication (injectable naltrexone) or risks for opioid use during the study
Liver enzymes that are three times higher than the upper limit of normal
Current use of benzodiazepine
Acute narrow-angle glaucoma
Severe sleep apnea---clinically determined by a physician
