Remote Ischemic Conditioning in Patients With Ulcerative Colitis

Exclusion Criteria

• •Pancolitis or acute severe ulcerative colitis requiring immediate treatment
• •Need for admission due to active ulcerative colitis
• •Ulcerative colitis with systemic symptoms (abdominal pain, fever \> 37.5 degrees, weight loss exceeding 3 kilograms).
• •Patient with anemia (Haemoglobin \< 8.3 mmol/l for males and \< 7.3 mmol/l for females).
• •Patient with ostomy or pouch.
• •The patient has had a bowel resection (except appendectomy)
• •The patient has constipation and/or another known bowel condition than ulcerative colitis such as IBS.
• •The patient has diabetes.
• •Regular intake of acetylsalicylic acid or NSAIDs
• •The patient cannot understand the information material.
• •The patient has had colon cancer, dysplasia or adenomatous polyps in the colon during the recent 5 year
• •The patient is in a poor general condition.
• •The patient has had a food poisoning within the last three months.
• •The patient is pregnant at the time of inclusion or has planned pregnancy during the period of study.
• •The patient is in medical treatment with cyclosporine at the beginning of the run in period.
• •Treatment for ulcerative colitis treatment has been changed within two weeks before the first day in the run in period
• •The patient has commenced treatment with azathioprine, 6-mercaptopurine or methotrexate within 12 weeks before the first day in the run in period.
• •The patient has commenced treatment with TNF-α inhibitors within 12 weeks before the first day of the run in period.
• •The patient suffers from coeliac disease or lactose intolerance.
• •Antibiotic treatment within two weeks before the first day of the run in period.
• •Patient has any medical, surgical condition that excludes the use of RIC.