Sitagliptin in Non-Diabetic Patients Undergoing Cardiac Surgery

Exclusion Criteria

• •Patients with hyperglycemia (blood glucose \> 125 mg/dL); or glycated hemoglobin (HbA1c) \> 6.5%; or previous treatment with oral antidiabetic agents or insulin
• •Severely impaired renal function (serum creatinine ≥3.0 mg/dL or GFR \< 30 mL/min) or clinically significant hepatic failure
• •Moribund patients and those at imminent risk of death (brain death or cardiac standstill)
• •Subjects with gastrointestinal (GI) obstruction or adynamic ileus or those expected to require GI suction
• •Patients with clinically relevant pancreatic or gallbladder disease
• •Treatment with oral or injectable corticosteroid
• •Mental condition rendering the subject unable to understand the scope, and consequences of the study
• •Female subjects who are pregnant or breast feeding at time of enrollment into the study