CryptoART Study: Decreasing Mortality Associated With Initiation of Antiretroviral Therapy in Sub-Saharan Africa

Exclusion Criteria

• •Presence of clinical symptoms suggestive of meningitis.
• •Recent history of CM within 2 weeks of enrollment, i.e., participants within the induction phase of therapy.
• •Individuals with severe hepatic injury, jaundice, alanine transferase (ALT) \>5x upper limit of normal
• •Individuals with renal failure, defined by an estimated Glomerular filtration rate (eGFR) ≤30 mL/min (using MDRD (Modification of Diet in Renal Disease) equation)
• •Currently known to be pregnant
• •A negative urine pregnancy test is required for study entry for women with childbearing potential.
• •The use of contraception will be recommended to women with childbearing potential while on high dose fluconazole therapy. Referral to family planning services will be given as necessary.
• •Previous allergy or other reaction to amphotericin B and/or fluconazole
• •Currently enrolled in another clinical trial/study