Prebiotic Effects of Isomalto-oligosaccharide

Exclusion Criteria

• •History of colon cancer
• •History of rheumatoid arthritis
• •Active self-reported febrile illness (may enroll after 2-week waiting period following the day that the illness/fever is resolved)
• •Taking TNF-alpha inhibitors, COX2 inhibitors, JAK inhibitors
• •History of hypothyroidism (with or without treatment)
• •History of inflammatory bowel disease (ulcerative colitis and Crohn's disease)
• •Type I or Type II diabetes
• •History of Parkinson's Disease, Huntington's Disease or Multiple Sclerosis
• •History of major depression, bipolar disorder, or schizophrenia
• •Pregnant or lactating women
• •Currently suffering from migraine headaches (at least one migraine headache in the past 30 days)
• •Current use of any prescription or non-prescription weight loss products
• •Consumption of more than 2 drinks per day of alcohol
• •Tobacco smoker (over ½ pack per week is excluded)
• •Marijuana smoker (over once per month is excluded)
• •Currently have an eating disorder including anorexia nervosa, bulimia, and/or obsessive compulsive disorders
• •Plan to start a new diet or make changes to their current diet during the study
• •Diagnosis of Coronary Artery Disease who have had chest pain within the past 2 months
• •Diagnosis of Congestive Heart Failure who have had any episodes of shortness of breath within the last 2 months
• •History of stroke within the past 1 year
• •History of ventricular tachycardia or fibrillation
• •History of hypertension that has been difficult to control with medication (based on medical history - e.g. requiring more than 2 medication to achieve control)
• •History of seizures in the last 5 years
• •Cancer diagnosis in the last 5 years (except non-melanoma skin cancer or in-situ cervical cancer)
• •History of bariatric or lapband surgery
• •Usual or planned consumption of more than 2 servings per week of yogurt, kombucha, kefir, or kimichi
• •Regular use of antibiotics
• •Use of antibiotics in the previous 2 weeks
• •Current and continued use of prebiotics or probiotics
• •Known allergic reactions to components of the study supplement or placebo