1. Acute limb ischemia

2. Procedure includes device deployment that has specific FDA regulations for anticoagulation/anti-platelet medication regimen.

3. Patient undergoing atherectomy procedure

4. Intervention includes deployment of drug eluted stent

5. Critical limb ischemia (Rutherford Classification 6)

6. Thrombocytopenia: Platelet count \<50k

7. Liver disease (Childs-Pugh B or C)

8. Existing need for on going clopidogrel therapy

9. Proton Pump Inhibitor Use (If unable to be switched)

10. Need for therapeutic anticoagulation

11. Known hypercoagulable disorder

12. Allergy or contraindication to aspirin or clopidogrel

13. Pregnancy

14. Patients enrolled in another investigational drug or device study within the past 30 days

Short vs Long Duration Dual Antiplatelet Therapy in Patients Undergoing Lower Extremity Endovascular Revascularization