Trial of Simvastatin for the Treatment of Severe Asthma

Exclusion Criteria

• •1. baseline FEV1 \<30% predicted,
• •2. current smokers or ex-smokers with \>5 pack-years of smoking history,
• •3. pregnant women, nursing/lactating mothers, or women of childbearing potential who are actively attempting to become pregnant,
• •4. nasal or sinus surgery or trauma within 3 months of study participation,
• •5. ischemic heart disease,
• •6. liver disease, and
• •7. the concurrent use of the following medications (amiodarone, verapamil, diltiazem, gemfibrozil, cyclosporine, antifungal azoles (itraconazole, ketoconazole, or voriconazole), and danazol.