Evaluation of Renal Function Impairment on the Pharmacokinetics of LEE011

Exclusion Criteria

• •Subject has received a renal transplant at any time in the past and is on immunosuppressant therapy
• •History or presence of impaired cardiac function
• •Any surgical or medical condition that may significantly alter the absorption, distribution, metabolism, or excretion of drugs
• •Administration of CYP3A4/5 inhibitors or inducers or CYP3A4 substrates with narrow therapeutic windows
• •Administration of medications that prolong the QT interval
• •Subject has a history of immunodeficiency diseases, including HIV, as confirmed by (HIV-1, HIV-2) test
• •Receipt of investigational product in another clinical trial within 4 weeks of dosing
• •Severe albuminuria \> 300 mg/day
• •Subjects undergoing any method of dialysis
• •Subjects with renal impairment due to hepatic disease (hepatorenal syndrome)
• •Other protocol-defined Inclusion/Exclusion may apply.