Vaginal Progesterone for the Prolongation of Pregnancy After Arrested Pre-term Labor

Exclusion Criteria

• •1. Contraindication to ongoing pregnancy including:
• •1. Suspected amnionitis during testing for eligibility- evidence of active infection including temperature ≥ 38.0°C and uterine tenderness, foul-smelling vaginal discharge, maternal tachycardia of 120 beats per minute or greater, or sustained fetal tachycardia of 160 beats per minute or greater
• •2. Evidence of significant placental abruption (contractions and significant bleeding from placental origin)
• •3. Intrauterine fetal death diagnosed at the time of admission
• •2. Major fetal malformation
• •3. Known maternal allergy to progesterone
• •4. Current use of progesterone at the time of admission
• •5. Epilepsy
• •6. Breast cancer
• •7. PPROM (preterm premature rupture of membranes) during testing for eligibility
• •8. Age below 18 years
• •9. Known active liver disease (elevated liver enzymes at twice the upper normal limit according to medical history or blood test that were taking doring standard medical care)
• •10. History of deep vein thrombosis
• •11. Major active psychiatric disorders (major affective disorders and psychotic disorders)
• •12. Uncontrolled chronic hypertension
• •13. Heart failure
• •14. Chronic renal failure
• •15. Pre-gestational diabetes with known target organ damage
• •16. History of spontaneous preterm delivery
• •17. Previous tocolytic treatment during the current pregnancy