Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Memorial Sloan Kettering Cancer Center
Age
18–80
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Age 18-80
KPS ≥ 60
At least one recurrent or progressive brain metastasis (es) from any solid primary tumor that is visible on MRI as assessed by the patient's treating physician.
Recurrence may occur after any treatment: recurrence after whole-brain radiation, stereotactic radiosurgery, surgical resection, systemic chemotherapy are all acceptable.
There is no limit on the number of brain metastases.
Surgical resection or SRS to other recurrent lesions in the same patient are acceptable, provided one recurrent lesion remains untreated.
Systemic disease must be well-controlled or NED in the opinion of the patient's primary oncologist.
You may not be if
Inability to get brain MRI +/- contrast
Progressive systemic disease
Known leptomeningeal metastases
Primary Brain tumor
Active Intracranial Hemorrhage
Surgery less than two weeks before enrollment
GI hemorrhage (active or in recent 6 months)
Concurrent anti-platelet therapy
Concurrent anti-coagulation therapy
Active bleeding diathesis
Platelet count ≤ 70,000/mm3
International normalized ratio (INR) \> 1.6 and a Partial Thromboplastin Time (PTT) \> 40 seconds
Serum Creatinine \>2 mg/dL OR CrCL \<30ml/min
AST or ALT \> 200 U/L
Hemoglobin \<8 g/dL
Allergy to meclofenamate or other NSAID
Inability to tolerate PO dosing
Steroid dose increased in the most recent two weeks.
Pregnancy
Cardiac Arrhythmia requiring medical management and/or pacemaker.
Known congestive heart failure requiring medical management
