uncontrolled hypertension or recent (\<3 weeks) titration of blood pressure medications
clinically significant volume overload on screening physical examination
selected medical conditions other than kidney disease and hypertension (active cancer, chronic liver failure, moderate to severe COPD, New York Heart Association class 2 or greater congestive heart failure, obstructive sleep apnea requiring nightly continuous positive airway pressure, solid organ transplant)
use of alkali supplementation
body mass index \<18.5 or \>40 kg/m2
ideal body weight \<45.5 kg
anemia at screening (hematocrit \<29% in participants with kidney disease or \<33% in healthy participants)
pregnancy or breastfeeding
allergies, intolerance or unwillingness to consume foods or supplement provided in feeding menu
serum calcium less than 8.6 mg/dl on screening laboratories
