Males, Antioxidants, and Infertility Trial

Inclusion Criteria

• •12 or more months of infertility (primary or secondary)
• •Heterosexual
• •Cohabitating and able to have regular intercourse
• •Male:
• •≥ 18 years of age
• •At least one abnormal semen parameter on a semen analysis within the past 6 months:
• •* Sperm concentration ≤15 Million/ml
• •* Total motility ≤40%
• •* Normal morphology (Kruger) ≤4%
• •* DNA fragmentation (SCSA, DNA fragmentation index) \>25%
• •Female:
• •≥18 years of age and ≤40 years of age
• •For women ≥ 35 years of age, evidence of normal ovarian reserve as assessed by menstrual cycle day 3 (+/-2 days) FSH ≤10 IU/L with estradiol ≤ 70 pg/mL, AMH ≥ 1.0 ng/mL, OR antral follicle count \>10 within one year prior to study initiation.
• •Evidence of at least one patent fallopian tube as determined by an hysterosalpingogram or laparoscopy showing at least one patent fallopian tube or a saline infusion sonogram showing spillage of contrast material
• •Regular cycles defined as ≥25 days and ≤35 days in duration
• •Evidence of ovulation including biphasic basal body temperatures, positive ovulation predictor kits, or progesterone level ≥3 ng/ml.