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TiLE (Time Lapse Eeva) Clinical Trial | Clinical Trials | Clareo Health

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COMPLETEDPhase 4NCT02417441

TiLE (Time Lapse Eeva) Clinical Trial

The purpose of the study was to explore the added value of adjunctive use of Early Embryo Viability Assessment (Eeva) with morphological grading in identifying optimal embryos for transfer.

Lead sponsor: Merck KGaA, Darmstadt, Germany•23 locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

Merck KGaA, Darmstadt, Germany

This study is a Phase IV, open label, prospective, randomized, exploratory, multicenter study. Subjects were randomized in 2:1 ratio to two treatment groups: in the experimental group, embryos were assessed for embryo transfer (ET) with Eeva and morphological grading, while in the control group embryos were assessed with morphological grading only.

Age

18 - 40 years

Sex

FEMALE

Healthy Volunteers

Yes

Inclusion Criteria

•All infertile subjects treated with In vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI)
•Subject age less than or equal to (\<=) 40 years
•Less than or equal to (\<=) 3 failed IVF/ICSI cycles
•At least 4 normally fertilized eggs (2 pronuclei \[2PN\]) in current cycle
•Normal uterine cavity
•Fertilization using only ejaculated sperm (fresh or frozen)
•Subject must have read and signed the Informed Consent Form

Exclusion Criteria

•Have clinically significant systemic disease
•Have abnormal, undiagnosed gynecological bleeding
•Have any contraindication to Controlled Ovarian Stimulation (COS) for assisted reproductive technologies (ART) and to gonadotropins to be used in ART
•Egg donor cycle
•Planned "freeze all" cycle (oocytes or embryos)
•Concurrent participation in another clinical trial

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: January 30, 2020Terms

Trial snapshot

StatusCOMPLETED

PhasePHASE4

Enrollment976

Start dateJun 2015

Last updatedJan 30, 2020

Condition

Locations shown

Cambrian Wellness Centre

Calgary, Alberta

One Fertility

Burlington, Ontario

ISIS Regional Fertility Clinic

Mississauga, Ontario

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: January 30, 2020Data synced to Clareo: May 25, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions