Effect and Tolerance of Botulinum A Toxin Rectal Injections on Fecal Incontinence

Exclusion Criteria

• •Patients younger than 18 years old;
• •Pregnant or breast-feeding women or women without effective contraception and of age to procreate;
• •Exclusive passive Fecal Incontinence;
• •Fecal Incontinence secondary to anorectal malformation, post-surgery, anorectal organic disease (cancer, inflammatory bowel disease, post-radiotherapy etc.), constipation, an anal sphincter lesion which could be repaired as a first step, a rectal prolapse (the inclusion in the study is possible if Fecal Incontinence persists after rectopexy, a neurological disease with rapid progress ( stable neurological status is needed for at least 6 months);
• •Patients under guardianship.
• •Known Hypersensibility to botulinum toxin;
• •Neuromuscular junction pathology (myasthenia, Lambert-Eaton syndrome);
• •Anesthesia performed less than 1 month previously;
• •Association with antibiotics
• •Neurological pathology such as polyradiculoneuropathy;
• •Dysphagia, pneumopathy secondary to dysphagia;
• •Botulinum toxin injections during the 3 months before the beginning of the study;
• •Known Hypersensitivity to albumin;
• •History of inhalation pneumopathy.
• •Rectoscopy impossible (anal stenosis for example);
• •Anti-coagulant or anti-platelet drug or hemostasis disorders.