Loading clinical trials...

Comparative Trial of IV Lacosamide Versus Phenytoin for Seizure Management | Clinical Trials | Clareo Health

TERMINATEDPHASE4

Comparative Trial of IV Lacosamide Versus Phenytoin for Seizure Management

Prospective, Randomized, Single-blinded Comparative Trial of IV Lacosamide Versus Phenytoin for Seizure Management

NCT02409433•London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Summary

The Investigator plans to perform a prospective, randomized, single blinded, study that will compare patients treated with IV lacosamide to those treated with Phenytoin in the Intensive Care Unit (ICU) setting. The investigator will also evaluate the rate of clinically evident and sub-clinical seizures, and to compare long-term outcomes between patients treated with lacosamide and those treated with Phenytoin.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Traumatic Brain Injury (TBI) or Subarachnoid hemorrhage (SAH)
•Admitted to the hospital less than 48 hours prior to randomization
•Glasgow Coma Scale (GCS) score 3-8 (inclusive), or GCS motor score of five or less and abnormal CT scan showing intracranial pathology
•Hemodynamically stable
•Older than 18 years of age

Exclusion Criteria

•No IV access
•Spinal cord injury
•History of or CT confirmation of previous brain injury, including brain tumor, stroke, or a spontaneous intracerebral hemorrhage
•Hemodynamically unstable
•Suspected anoxia
•Liver failure
•Younger than 18 years of age
•Pregnant
•Allergy to phenytoin or lacosamide
•Inability to obtain consent

Locations (1)

University Hospital

London, Ontario, Canada

Key Dates

Start Date

August 1, 2014

Primary Completion Date

November 1, 2015

Completion Date

November 1, 2015

Last Updated

January 7, 2016

Enrollment

ACTUAL participants

Conditions

Seizures

Interventions

lacosamide

DRUG

Phenytoin

DRUG

A Study to Test the Efficacy and Safety of Staccato Alprazolam in Study Participants 12 Years of Age and Older With Stereotypical Prolonged Seizures

NCT05077904

Stereotypical Prolonged Seizures

View study

RECRUITINGPHASE3

A Study to Evaluate XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures

NCT05667142

Primary Generalized Tonic-Clonic Seizures

View study

RECRUITINGPHASE3

LEvetiracetam to Prevent Seizures in Symptomatic Alzheimer's Disease in Adults With Down Syndrome

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: January 7, 2016Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Comparative Trial of IV Lacosamide Versus Phenytoin for Seizure Management

Inclusion Criteria

Exclusion Criteria

A Study to Test the Efficacy and Safety of Staccato Alprazolam in Study Participants 12 Years of Age and Older With Stereotypical Prolonged Seizures

A Study to Evaluate XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures

LEvetiracetam to Prevent Seizures in Symptomatic Alzheimer's Disease in Adults With Down Syndrome

Longitudinal Study of Neurogenetic Disorders

SPN-817 Open-Label Extension Study in Adults With Focal Onset Seizures

Pharmacological Modulation of Brain Oscillations in Memory Processing