TRC105 Combined With Standard-dose Bevacizumab for Two Patients With Metastatic And Refractory Choriocarcinoma

Exclusion Criteria

• •1. Prior treatment with TRC105
• •2. Serious dose-limiting toxicity related to prior bevacizumab
• •3. Current treatment on another therapeutic clinical trial
• •4. Uncontrolled chronic hypertension defined as systolic \> 140 or diastolic \> 90 despite optimal therapy (initiation or adjustment of BP medication prior to study entry is allowed provided that the average of 3 BP readings at a visit prior to enrollment is \< 140/90 mm Hg)
• •5. Symptomatic pericardial or pleural effusions
• •6. Uncontrolled peritoneal effusions requiring paracentesis more frequently than every 2 weeks
• •7. Active bleeding or pathologic condition that carries a high risk of bleeding (i.e. hereditary hemorrhagic telangiectasia)
• •8. Thrombolytic or anticoagulant use (except to maintain i.v. catheters) within 10 days prior to first day of study therapy
• •9. Cardiac dysrhythmias of NCI CTCAE grade ≥ 2 within the last 28 days
• •10. Known active viral or nonviral hepatitis
• •11. Open wounds or unhealed fractures within 28 days of starting study treatment
• •12. History of peptic ulcer disease or erosive gastritis within the past 6 months, unless treated for the condition and complete resolution has been documented by esophagogastroduodenoscopy (EGD) within 28 days of starting study treatment
• •13. Known human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) related illness
• •14. Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation or may interfere with the interpretation of study results and, in the judgment of the Investigator, would make the patient inappropriate for this study