Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Masonic Cancer Center, University of Minnesota
Age
18–70
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Meets ONE of the following disease criteria:
1. Primary AML induction failure: no CR after 2 or more induction attempts
2. Relapsed AML or Secondary AML (from MDS or treatment related): not in CR after 1 or more cycles of standard re-induction therapy
3. AML relapsed \> 2 months after transplant: No re-induction required, and no more than 1 re-induction cycle is allowed.
4. Relapsed AML for patients \> 60 years of age the 1 cycle of standard chemotherapy is not required if either of the following criteria is met:
* Relapse within 6 months of last chemotherapy
* BM blast count \< 30% within 10 days of starting protocol therapy
Available related HLA-haploidentical donor (aged 14 to 75 years) by at least Class I serologic typing at the A\&B locus
Karnofsky Performance Status ≥ 60%
Patients must have adequate organ within 14 days (28 days for pulmonary and cardiac) of study registration
Able to be off prednisone or other immunosuppressive medications for at least 3 days prior to NK cell infusion (excluding preparative regimen pre-medications).
Agrees to use contraception prior to study entry and for the duration of study participation.
You may not be if
Bi-phenotypic acute leukemia.
Transplant \< 60 days prior to study enrollment.
Active autoimmune disease.
History of severe asthma
Uncontrolled intercurrent illness
New or progressive pulmonary infiltrates on screening chest x-ray or chest CT scan that has not been evaluated with bronchoscopy
Pleural effusion large enough to be detectable on chest x-ray.
Pregnant women
History of HIV, active or chronic hepatitis B, hepatitis C or HTLV-I infection
Known hypersensitivity to any of the study agents used
Received investigational drugs within the 14 days of study registration.
Known active CNS involvement.
Criteria For Initial Donor Selection:
Related donors (sibling, parent, offspring, parent or offspring of an HLA identical sibling).
14-75 years of age.
At least 40 kilogram body weight.
In general good health as determined by the evaluating medical provider.
HLA-haploidentical donor/recipient match by at least Class I serologic typing at the A\&B locus.
Not pregnant.
Able and willing to undergo apheresis.
Clareo Health | MT2014-25: Haplo NK With SQ IL-15 in Adult Relapsed or Refractory AML Patients
