Hypothermia Therapy in Pediatric Cardiac Intensive Care Unit for Suspected for Brain Injury

Inclusion Criteria

• •1. Every child entering the PCICU, age \< 7 years
• •2. The child will enter arm 1 or 2 if he underwent the event described in section 3.
• •3. Hypoxic ischemic event that would render hypothermia treatment is defined as
• •* During the hospitalization in the PCICU before or after the surgery:
• •Resuscitation comprised of chest compressions for more than 2 minutes, and the first blood tests immediately after the resuscitation show a serum lactate level of more than 90 mg/dl OR Resuscitation comprised of chest compressions for more than 2 minutes, and the first blood tests immediately after the resuscitation shows a serum lactate level of more than 40 mg/dl and a blood pH level of less than 7.1
• •* During the surgery Near infra red spectroscopy lower than 40 for more than 5 minutes AND Serum lactate levels of more than 90 mg/dl during the event OR The patient is re-connected to cardio-pulmonary bypass machine as a result of the event
• •4. Initiation of hypothermia treatment within 6 hours following the hypoxic ischemic event defined in section 3.
• •Prolonged low cerebral perfusion before the PCICU admission, with 3 repeated tests in 1 hour of lactate level higher than 40 mg/dl and pH lower than 7.1
• •Rejection criteria
• •A second resuscitation after the hypoxic ischemic event and before a brain MRI is done