The Potential for Metformin to Improve Tumor Oxygenation in Locally Advanced Cervix Cancer: A Phase II Randomized Trial

Exclusion Criteria

• •Evidence of distant metastases
• •Receiving any other investigational agents concurrently or within 4 weeks.
• •Known diabetes mellitus.
• •Currently taking metformin, sulfonylureas, thiazolidinediones or insulin.
• •History of allergic reactions attributed to compounds of similar chemical or biologic composition to metformin or cisplatin.
• •Any condition associated with increased risk of metformin-associated lactic acidosis
• •Uncontrolled inter-current illness
• •Pregnant women
• •History of another invasive malignancy, except for non-melanoma skin cancer or tumors curatively treated with no evidence of disease for \>=5 years.
• •Known HIV-positive
• •History of bowel obstruction or malabsorption syndromes
• •History of active clinically significant bleeding
• •Contraindications to radiotherapy
• •Taking drug disulfiram (antabuse).