Copenhagen Comorbidity in HIV Infection Study

Primary hypothesis: Cardiovascular disease: \- HIV infection is independently associated with higher prevalence of coronary atherosclerosis (assessed by CT angiography) Obstructive pulmonary disease: \- HIV infection is independently associated with higher prevalence of COPD, and independently associated with loss of lung function Liver disease: \- HIV infection is independently associated with liver steatosis, steatohepatitis and liver fibrosis Lipid and fat metabolism: \- HIV infection is independently associated with alterations in adipose fat tissue and dyslipidemia Secondary hypothesis: Cardiovascular disease: * Viral load and CD4 are independently associated with coronary atherosclerosis (assessed by CT angiography) in HIV-infected individuals. * Levels of inflammatory markers can predict coronary atherosclerosis in HIV-infected individuals. * Microbial translocation and metabolism are associated with coronary atherosclerosis in HIV-infected individuals. * Endothelial dysfunction (assessed by arterial elastography) can predict coronary atherosclerosis in HIV-infected individuals Obstructive pulmonary disease: * Viral load and CD4 is independently associated with emphysema * HIV is independently associated with pulmonary hypertension (assessed by CT angiography), and obstructive lung disease is independently associated with airway obstruction * PCP colonization in HIV infected patients is independently associated with obstructive lung disease, emphysema and loss of lung function. * Inflammatory markers in HIV infected patients are associated with obstructive lung disease and loss of lung function