Lead Sponsor

University Hospital Tuebingen

Age

18 - 80 years

Sex

ALL

Healthy Volunteers

No

•1. In MRI suspected primary singular untreated GBM
•2. Planned total resection of the tumor according to the surgeon
•3. Patient ≥18 years, ≤80 years
•4. Preoperative KPS ≥ 60%, American Society of Anesthesiologists (ASA) score 1 and 2
•5. Patients' informed consent

•1. Tumors of the midline, basal ganglia, cerebellum, brain stem, eloquent areas
•2. Multifocal glioblastoma
•3. Substantial (\>50%), non-contrast enhancing tumor areas suggesting low-grade glioma with malignant transformation
•4. Contraindications to MRI
•5. Inability to give consent because of language barrier or dysphasia
•6. Histological diagnosis other than Glioblastoma multiforme WHO °IV
•7. Increased risk of thrombosis (e.g. Factor V Leiden)
•8. Pregnancy or breast feeding
•9. Hypersensibility for 5-ALA oder porphyrins
•10. Acute or chronic Porphyria
•11. Renal insufficiency
•12. Hepatic insufficiency
•13. High likelihood of inability to receive adjuvant therapy

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