The Addition of Chloroquine to Chemoradiation for Glioblastoma

Exclusion Criteria

• •Prior radiotherapy
• •Prior chemotherapy
• •Recent (\< 3 months) severe cardiac disease (NYHA class \>1) (congestive heart failure, infarction)
• •History of cardiac arrythmia (multifocal premature ventricular contractions, uncontrolled atrial fibrillation, bigeminy, trigeminy, ventricular tachycardia) which is symptomatic and requiring treatment (CTC AE 4.0), or asymptomatic sustained ventricular tachycardia. Asymptomatic atrial fibrillation controlled on medication is allowed.
• •Cardiac conduction disturbances or medication potentially causing them
• •Treatment with investigational drugs in 4 weeks prior to or during this study
• •If the subject has clinically significant and uncontrolled major medical condition(s) including but not limited to:
• •* uncontrolled nausea/vomiting/diarrhea:
• •* active uncontrolled infection, including HIV and hepatitis (HBV, HCV)
• •* psychiatric illness/social situation that would limit compliance with study requirements
• •* any medical condition, with the opinion of the study investigator, places the subject at an unacceptably high risk for toxicities.
• •The subject has had another active malignancy within the past 3 years except for any cancer in situ that the principal Investigator considers to be cured.
• •Chronic systemic immune therapy (with the exception of corticosteroids)
• •Concurrent cytochrome P450 enzyme-inducing anticonvulsant drugs (e.g., phenytoin, carbamazepine, phenobarbital, primidone, or oxcarbazepine)
• •Known glucose-6-phosphate dehydrogenase deficiency
• •Psoriasis or porphyria
• •Known hypersensitivity to 4-aminoquinoline compound
• •Retinal or visual field changes unrelated to the tumor location prior to 4-aminoquinoline compound use