Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Istituto Clinico Humanitas
Patients treated with Hypofractionated Whole Breast Irradiation (WBI) received SIB irradiation of the whole breast and surgical bed at two different dose levels. Dose prescription was 40.5 Gy to PTVWB and 48.0 Gy to PTVboost in 15 fractions over 3 weeks, with simultaneous integrated boost delivering 2.7 and 3.2Gy/fraction for each PTV respectively. Daily image guided radiotherapy (IGRT) were generated before each treatment session in each patient to verify the set-up.
Accelerated Partial Breast Irradiation (APBI) using external intensity -modulated radiotherapy (VMAT RA) was delivered at a dose of 30 Gy in five 6-Gy/day fractions over 10 days (every other day) with IGRT at each treatment.
Age
55–70
Sex
FEMALE
Healthy volunteers
Not accepted
You may be eligible if
55\< Age \<70
Tumor size ≤ 2 cm
pN0 (SN biopsy or ALND)
ER/PgR positive
Margins \> 5 mm (either at initial surgery or at re-excision)
Clips placed in the surgical bed (minimum of 4 clips)
Unicentric only
No lymphovascular invasion
Any grade
No extensive intraductal component (\>25%)
Written informed consent
You may not be if
Prior thoracic radiation therapy
Oncoplastic surgery / No clips in the surgical bed
Multicentric cancer
Autoimmune disease, vasculitis, collagenopathy or scleroderma that may predispose to late sequelae
