History of any surgical or medical condition which might significantly alter the absorption, distribution, metabolism or excretion of drugs

Subjects with ongoing alcohol or drug abuse

Symptoms or history of encephalopathy (Grade 2 or above)

History or presence of liver disease or liver injury (healthy volunteers only)

History or presence of impaired renal function

Clinical evidence of severe ascites.

Total Bilirubin \> 6 mg/dL,

Subjects with a serum free cortisol test results that is below the lower limit of normal (based on central laboratory) during the screening period

Concomitant use of a drug that is a strong inducer of the CYP3A4/5 pathway

A Phase 1 Study of Osilodrostat (LCI699) in Healthy Volunteers and Subjects With Impaired Hepatic Function