Proteomic Analysis in Sera From Patients With Erosive Hand Osteoarthritis

Inclusion Criteria

• •Female gender
• •Less than 70 years old
• •Diagnosis of hand osteoarthritis according to ACR criteria ACR after exclusion of thumb base osteoarthritis:
• •1. Hand pain, aching or stiffness most of the days during the preceding month
• •2. Hard tissue enlargement of at least two of 8 selected joints \*
• •3. Hard tissue enlargement of at least two distal interphalangeal joint
• •4. Swelling of fewer than three metacarpophalangeal joint
• •5. Deformity of at least one of 10 selected joints \* Patients have to fulfil criteria 1, 2 AND 3 + 4 OR 5 \* the 8 selected joints are the second and third distal interphalangeal joint and the second and third proximal interphalangeal of both hands Then confirm by experts' committee
• •Exclusively symptomatic treatment
• •For women of child-bearing age, use of an effective contraceptive method
• •French spoken and read