Islet Transplantation Through an Indwelling Catheter in the Umbilical Vein

Exclusion Criteria

• •age \<18 years or \>60 years
• •diabetic history \<5 years
• •BMI\>27
• •body weight \>80kg
• •exogenous insulin requirement \>1 unit/kg/day
• •severe anemia (male \<8g/dl, female \<7g/dl)
• •low white blood cell count (\<3000/dl)
• •liver dysfunction
• •Symptomatic peptic ulcer disease
• •Any malignancy
• •Active infection including hepatitis B, hepatitis C, HIV, or TB
• •panel reactive antibody \>20%
• •Any medical condition that, in the opinion of the investigator, will interfere with the safe completion of the trial.