The Locus Coeruleus and Memory

Inclusion Criteria

• •For the patients:
• •diagnosis of prodromal Alzheimer's disease based on the latest research criteria (clinical assessment at the memory clinic : presence of at least a memory impairment, memory complaints expressed by the patient or informant, no problems in daily life functioning, no dementia and presence of biomarkers
• •Clinical Dementia Rating score of 0.5 (
• •Mini-Mental State Examination (MMSE) ≥ 23 and being mentally competent (in general, individuals with a MMSE ≥ 18 are considered mentally competent)
• •Age: between 60 and 85 years old
• •50% female
• •Right-handedness
• •Average level of education
• •Informed consent before participation in the study
• •For the healthy older individuals:
• •Average neuropsychological test results, in accordance with normative data, corrected for age, education and gender
• •No substantial memory complaints (according to the participant)
• •Age: between 60 and 85 years old
• •50% female
• •Right-handedness
• •Average level of education
• •Informed consent before participation in the study