Novel Type 2 Diabetes Mellitus Preventive Therapies

Because of recruitment difficulties the design was modified several times until April 2013 when we were able to increase recruitment. The following changes were made from initial to final study design: 1. Study moved from Clinical and Translational Science Institute (CTSI) to clinical setting (Nutrition and Fitness for Life Clinic) 2. Ages eligible expanded from 12-19 years old to 12-19.9 years old 3. Ethnicity/Race expanded from Hispanic only to include all races/ethnicities 4. Patients without a past family history of T2DM were made eligible 5. Study period was shortened from 6 months to 12-14 weeks 6. Number of required visits were reduced from 5 visits to 3 visits (all of which took place during regularly scheduled clinic appointments) 7. Open labeled but still randomized 8. Those in the Glutamine arm were provided lifestyles change intervention 9. Glycosylated hemoglobin (A1C) used instead of fasting Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) 10. Non-fasting blood draw rather than a fasting blood draw was instituted