RDEA3170 Bioavailability Study

Exclusion Criteria

• •Subject has a history or suspicion of kidney stones
• •Subject has undergone major surgery within 3 months prior to Screening
• •Subject donated blood or experienced significant blood loss (\> 450 mL) within 12 weeks prior to Day 1 or gave a plasma donation within 4 weeks prior to Day 1
• •Subject has inadequate venous access or unsuitable veins for repeated venipuncture
• •Subject has a Screening serum creatinine value above the upper limit of normal during Screening or at Day -2 (Admission)
• •Subject cannot swallow multiple tablets
• •Subject is a heavy caffeine drinker
• •Subject is unwilling to comply with the dietary restrictions of the study
• •Subject is unable or unwilling to comply with the study requirements or has a situation or condition that, in the opinion of the Investigator, may interfere with participation in the study