PET/CT Imaging of Angiogenesis in Lung or Head and Neck Cancers Prior or During Chemotherapy With Antiangiogenic Agents

Inclusion Criteria

• •1A. Male or female \> 18year old with non-small cell lung carcinoma (NSCLC) meeting the following criteria :
• •advanced NSCLC proven by histology or cytology, treatment including an agent with antiangiogenic effect scheduled
• •Measurable lesions \> 1 cm in short axis.
• •Pretherapeutic contrast-enhanced CT of thorax and upper abdomen available for masked reading on appropriate medium
• •FDG PET/CT available for masked reading on appropriate medium
• •1B. Male or female \> 18year old with head and neck (H\&N) cancer meeting the following criteria:
• •advanced H\&N cancer proven by histology or cytology, treatment including an agent with antiangiogenic effect scheduled
• •Measurable lesions \> 1 cm in short axis.
• •Pretherapeutic native and contrast enhanced CT or MRI of the head and neck available for masked reading on appropriate medium
• •FDG PET/CT available for masked reading on appropriate medium
• •Oto-rhino-laryngologic (ORL) examination including ORL fibroscopy and/or optionally panendoscopy.
• •2\. Capacity to remain without movement during the PET/CT examination 3. ECOG performance status ≤ 2 at inclusion 4. Patient with life expectancy ≥ 24 weeks after inclusion. 5. In fertile females, at inclusion the pregnancy must be ruled out 6. Volunteer and capable to follow necessary instructions during the trial 7. Informed consent signed by the patient 8. Affiliation to a social security system