Beijing Shijitan Hospital, Capital Medical University
patients were divided into 3groups: Group A:TFP+MTX (week0-week60) Group B:TFP+MTX+HCQ+SSZ(week0-week12) and then MTX+HCQ+SSZ(week13-week60) Group C:TFP+MTX (week0-week12) and then MTX (week13-week60)
Age
18–70
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Fulfill 2010 EULAR/ACR RA dignose criteria
Age18-70 years old
Have been teated regularly for 3 months
Disease duration \> 6months
DAS28\>3.2
You may not be if
Received surgical operation in 8 weeks
Received other biological agent (eg. rituximab, anti-TNF agents, anti-IL6 agents)in 6 months;
Injection of steroid in 4 weeks
Coexisting with other CTD except for SS
With severe and not controled cardiac vescular disease, neurological disease, pulmonary disease (including COPD and ILD), renal disease, liver disease, endocrine disease and Gastric Intestinal Disease
With not controled diseases including asthma, IBD and psoriasis needing oral or injection of steroid
Active infection with T\>38℃. Patients need admitted into hospital or biotics injection in 4 weeks or need oral biotics in 2 weeks
Malignant history.
Serum creatinine \>130 µmol/L
AST/ALT higher than 2 times upper level
platelet count\<100 x 109/L，or white blood count\<3 x 109/L
Interstitail lung disease: Chest X Ray
Hands X Ray ACR radiology staging shows IV stage RA
Pregnancy or planing to pregnant in 2 years or suckling period women.
