Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
UMC Utrecht
A total of twenty-five patients will be treated with a single dose preoperative ablative radiation treatment. After a vigilant follow-up with MRI, breast conserving surgery will be performed 6 months after the ablative radiation treatment. The total follow-up time is 10 years.
This study aims to present an ablative radiotherapy treatment approach that could resolve to some extent the disadvantages of current breast conserving treatment in elderly low-risk breast cancer patients who are currently not treated according to guidelines due to co-morbidity.
Age
50–any
Sex
FEMALE
Healthy volunteers
Not accepted
You may be eligible if
WHO performance scale ≤2.
Females at least 50 years of age with unifocal cT1N0 breast cancer or females at least 70 years of age with an unifocal cT1-2(maximum 3 cm)N0 breast cancer:
\- Tumor size as assessed on MRI
On tumor biopsy:
* Non-lobular invasive histological type carcinoma.
* LCIS is accepted.
* ER positive tumor receptor.
Tumor negative sentinel node.
Adequate communication and understanding skills of the Dutch language.
You may not be if
Legal incapacity
Indication for chemotherapy or immunotherapy (i.e. patients with an indication for endocrine therapy are eligible)
BRCA gene mutation.
Previous history of breast cancer
Other type of malignancy within 5 years before breast cancer diagnosis. For adequately treated carcinoma in situ of the cervix or basal cell carcinoma of the skin no specific time span from breast cancer diagnosis is required for inclusion
Her2neu positive tumor.
Previous history of ipsilateral breast surgery and impaired cosmetic outcome, as assessed by the treating surgeon or radiation-oncologist.
Collagen synthesis disease.
Signs of extensive DCIS component on histological biopsy or mammogram.
Invasive lobular carcinoma.
MRI absolute contraindications as defined by the Radiology Department.
Nodal involvement with cytological or histological confirmation.
Treatment with neo-adjuvant systemic therapy.
Clareo Health | Single Dose Ablative Radiation Treatment for Early-Stage Breast Cancer
