Recent ESUS (between 7 days and 6 months), defined as:

Recent ischemic stroke (including transient ischemic attack with positive neuroimaging) visualized by brain imaging that is not lacunar, and

Absence of cervical carotid atherosclerotic stenosis\> 50% or occlusion, and

No atrial fibrillation after ≥ 24-hour cardiac rhythm monitoring, and

No intra-cardiac thrombus on either transesophageal or transthoracic echocardiography, and

No other specific cause of stroke (for example, arteritis, dissection, migraine/vasospasm, drug abuse)

Rivaroxaban Versus Aspirin in Secondary Prevention of Stroke and Prevention of Systemic Embolism in Patients With Recent Embolic Stroke of Undetermined Source (ESUS)