Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Texas Southwestern Medical Center
With
Agency for Healthcare Research and Quality (AHRQ)
Parkland Health and Hospital System
The University of Texas Health Science Center, Houston
Johns Hopkins Bloomberg School of Public Health
Age
21–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
As the risk of HCC is significant in those with cirrhosis regardless of age, gender, or race, we will include adult patients with cirrhosis of all ages (\> 21 years old), both sexes, and all races/ethnicities who speak English or Spanish.
Our study leverages Parkland's electronic medical record (EMR) and uses a novel EMR-enabled case-finding algorithm to identify patients with known cirrhosis, using ICD-9 codes, as well as those with unrecognized but suspected cirrhosis, using a set of laboratory data.
Patients with ICD-9 codes for cirrhosis or cirrhosis complication will be eligible for study enrollment if they meet the following criteria:
One or more encounter with ICD-9 codes 456.0, 456.1, 456.2, 456.21, 567.23, 572.2, 572.3, and 572.4; OR,
Two or more encounters with ICD-9 codes 571.2 and/or 571.5; OR,
One encounter with ICD-9 codes 571.2 or 571.5 from a Parkland primary care clinic, GI, or women's health center.
Patients with an AST to platelet ratio index (APRI) \> 1.5 in combination with a platelet count \< 300, and aspartate aminotransferase (AST) \< 1,000 during study enrollment will be eligible.
We will exclude patients who have known HCC or a suspicious appearing mass on imaging within six months prior to ascertainment of eligibility, as these patients require further diagnostic testing instead of routine screening. We will exclude patients with Child Pugh class C cirrhosis or other significant comorbid conditions with a life expectancy less than one year, (e.g., extrahepatic malignancy) because HCC screening is not recommended in these subgroups of patients.
Parkland patients ≥ 21 years of age
Diagnosis of cirrhosis or meets criteria for suspected cirrhosis
≥ 1 outpatient visit during 12 months prior to randomization
Contact information on file
English or Spanish speaking
You may not be if
HCC or suspicious mass on imaging
Any malignancy except malignant neoplasm of skin
Metastatic solid tumor
Palliative care referral
Liver transplant
Child Pugh C
Clareo Health | RCT of Screening Strategies Among Patients at High Risk for Developing HCC in a Safety-net Health System
