Transfusion-dependent\* females and males with thalassemia (any genotype) who are 12 to 45 years of age.

History of at least 5 years of chronic transfusion (defined as ≥ 8 transfusions/year) (Age of initiation of transfusions does not matter)

Any pubertal stage.

Liver iron evaluated by SQUID, MRI or liver biopsy within 12 months prior to enrollment in the study.

Need to be able to stop hormonal therapy for 3 weeks (males) and one month (females) prior to study enrollment.

Reproductive Capacity and Iron Burden in Thalassemia