SBRT Pre-operatively for Pancreatic Cancer

You may not be if

• 2. Histologically proven pancreatic ductal adenocarcinoma or cytological proven pancreatic malignancy.
• 3. Able to undergo biliary drainage using a stent.
• 4. Deemed fit and suitable for surgical resection.
• 5. No overt metastases or uncertain status with investigations suspicious of possible metastatic disease (e.g. small equivocal pulmonary nodule(s)).
• 6. Male or female, Age \>= 16 years.
• 7. Life expectancy of at least 6 months.
• 8. ECOG performance status 0- 1
• 9. The patient is willing and able to comply with the protocol for the duration of the study, and scheduled follow-up visits and examinations.
• 10. Written (signed and dated) informed consent and be capable of co-operating with protocol.
• 11. Haematological and biochemical indices within defined ranges.
• 1. Distant metastatic disease or local disease that cannot be encompassed in the SBRT field.
• 2. History of previous or concurrent malignancy diagnoses for which the expected prognosis is likely to be worse than that for the current diagnosis of pancreatic cancer (excludes for example: e.g. localised prostate cancer, early colorectal cancer, early breast cancer, curatively-treated basal cell carcinoma of skin, carcinoma in situ of cervix; curatively treated cancer of other sites who are recurrence free for \>3 years).
• 3. Serious medical or psychological condition precluding trial intervention.
• 4. Previous upper abdominal or right chest wall radiotherapy where 30% of the liver has received \>15Gy.
• 5. PPregnancy. Pregnant or breast-feeding women are ineligible. Women of childbearing potential must use effective methods of contraception.
• 6. Any other psychological, social or medical condition, physical examination finding or laboratory abnormality that the Investigator considers makes the patient a poor trial candidate or could interfere with protocol compliance or the interpretation of the trial results.