Mohs and Immunofluorescence for Malignant Melanoma In Situ

Inclusion Criteria

• •1. Male or female of any race and at least 18 years of age
• •2. Patient with biopsied proven Lentigo maligna (LM) in situ
• •3. Patient meets criteria for Mohs Micrographic Surgery (MMS)
• •1. The cancer is large
• •2. The edges of the cancer (clinical margins) cannot be clearly defined
• •3. Prior treatment has failed, i.e. recurrent tumor
• •4. The cancer is located in a cosmetically sensitive or functionally critical area of the body (such as eyelids, nose, ears, lips, fingers, toes, and genitals)
• •5. The histologic pattern of the cancer is aggressive
• •6. The patient is immunosuppressed
• •4. Patient with biopsied proven LM in situ located on an anatomic areas appropriate for MMS:
• •1. Area H: ''Mask areas'' of face (central face, eyelids \[including inner/outer canthi\], eyebrows, nose, lips \[cutaneous/mucosal/vermillion\], chin, ear and periauricular skin/sulci, temple), genitalia (including perineal and perianal), hands, feet, nail units, ankles, and nipples/areola.
• •2. Area M: Cheeks, forehead, scalp, neck, jawline, pretibial surface.
• •3. Area L: Trunk and extremities (excluding pretibial surface, hands, feet, nail units, and ankles).
• •5. Patient able to tolerate surgery
• •6. Patient is able to comply with appointments including follow-up appointments
• •7. Ability to understand and willingness to sign a written informed consent document