GLP-1 Agonism for Blocking Cocaine Euphoria and Self-Administration

Exclusion Criteria

• •1. Other drug dependence (except nicotine) as determined by urine toxicology or interview
• •2. \< 1 year of cocaine dependence,
• •3. a primary major DSM-IV psychiatric diagnosis (schizophrenia, bipolar disorder, etc.), unrelated to cocaine,
• •4. a history of significant medical (cardiovascular) or neurological illness, ie prior myocardial infarction, current active symptoms of cardiovascular disease / angina, evidence of cocaine-related cardiovascular symptoms, prior arrhythmias or need for cardiovascular resuscitation, neurovascular events such as transient ischemic attacks, stroke, and/or seizures Parameters re: elevations in vital signs are now explicitly specified under "Safety features built into our one-day self-administration paradigm).
• •5. current use of psychotropic and/or potentially psychoactive prescription medication,
• •6. seeking treatment for drug abuse/dependence (for experimental cocaine component),
• •7. physical or laboratory (β-HCG) evidence of pregnancy.
• •8. current use of any medication (prescription or over-the-counter) determined to cause potential drug interactions by the study physicians.