A Study to Evaluate ASP8232 in Reducing Central Retinal Thickness in Subjects With Diabetic Macular Edema (DME)

Exclusion Criteria

• •Subject's study eye has macular edema considered to be due to a cause other than DME
• •Subject's study eye has a decrease in BCVA due to causes other than DME that is likely to be decreasing BCVA by 3 lines or more
• •Subject's study eye has significant macular ischemia as shown on angiography
• •Subject's study eye has any other ocular disease that may cause substantial reduction in BCVA
• •Subject has active peri-ocular or ocular infection
• •Subject's study eye has a history of non-infectious uveitis
• •Subject's study eye has high myopia (-8 diopter or more correction)
• •Subject's study eye has a history of prior pars plana vitrectomy
• •Subject's study eye has a history of any ocular surgery within 3 months prior to Day 1
• •Subject's study eye has a history of YAG capsulotomy within 3 months prior to Day 1
• •Subject's study eye has a history of panretinal scatter photocoagulation (PRP) or focal laser within 3 months prior to Day 1 or anticipated need for PRP during the course of the study through the Week 12 visit
• •Subject's study eye has a history of prior IVT, subtenon, or periocular, non-sustained release, steroid therapy within 3 months prior to Day 1
• •Subject's study eye has a history of intravitreal sustained release dexamethasone therapy within 6 months prior to Day 1.
• •Subject's study eye has a history of intravitreal sustained release fluocinolone within 3 years prior to Day 1.
• •Subject's study eye has a history of prior treatment for DME with IVT anti-vascular endothelial growth factor (VEGF) treatment within 8 weeks prior to Day 1
• •Subject has a history of prior treatment with any other (than previously listed) approved treatment which is not labeled for DME within 1 year prior to Day 1
• •Subject's study eye has high-risk proliferative diabetic retinopathy (PDR)
• •Subject has uncontrolled glaucoma
• •Subject has media clarity, papillary constriction (i.e., senile miosis), or subject lacks cooperation that would interfere with any study procedures, evaluations or interpretation of data