Emergency Administration of EPI-743 to a Single Patient With Leber's Hereditary Optic Neuropathy [LHON]

Exclusion Criteria

• •Allergy to EPI-743 or sesame oil
• •Clinical history of bleeding or abnormal PT/PTT
• •Hepatic insufficiency with LFTs greater than 2-times normal
• •Renal insufficiency requiring dialysis
• •Fat malabsorption syndromes
• •Any other concurrent inborn erros of metabolism
• •Severe end-organ hypo-perfusion syndrome secondary to cardiac failure resulting in lactic acidosis
• •Anemia with a HCT \<25