Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Bayer
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Histologically or cytologically-proven metastatic CRC for which the decision of treatment with regorafenib was made
Previous treatment with fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, an anti-VEGF therapy, and, if KRAS wild type, an anti-EGFR therapy
Male or female patients ≥ 18 years of age
Eastern Cooperative Oncology Group performance status (ECOG PS) of 0 or 1
Signed informed consent obtained before any study specific procedure is performed.Patients must be able to understand and willing to sign the written ICF.
Life expectancy of at least 12 weeks
Adequate bone marrow, liver and renal function as assessed by the following laboratory requirements:
1. Total bilirubin ≤ 1.5 x the upper limits of normal (ULN)
2. Alanine aminotransferase (ALT) and aspartate aminotransferease (AST)
≤ 3.0 x ULN (≤ 5 x ULN for patients with liver involvement of their cancer)
3. Alkaline phosphastase limit ≤ 2.5 x ULN (≤ 5 x ULN for patients with liver involvement of their cancer)
4. Lipase ≤ 1.5 x the ULN
5. Amylase ≤ 1.5 x the ULN
6. Serum creatinine ≤ 1.5 x the ULN
7. International normalized ratio (INR) ≤ 1.5 x ULN and partial thromboplastin time (PTT) or activated partial thromboplastin time (aPTT) ≤ 1.5 x ULN unless receiving treatment with therapeutic anticoagulation. Patients being treated with anticoagulant (e.g., heparin), will be allowed to participate provided no prior evidence of an underlying abnormality in these parameters exists. Close monitoring of at least weekly evaluations will be performed until INR and PTT are stable based on a pre-dose measurement as defined by the local standard of care.
Estimated creatinine clearance (CLcr) ≥ 30 mL/min as calculated using the Cockroft-Gault (C-G) equation.
Women of childbearing potential must have a blood or urine pregnancy test performed a maximum of 7 days before start of study treatment, and a negative result must be documented before start of study treatment.
Women of childbearing potential and men must agree to use adequate contraception before entering the program until at least 8 weeks after the last study drug administration.
You may not be if
Unable to swallow oral medications.
Prior use of regorafenib
Previous assignment to treatment during this study. Patients permanently withdrawn from study participation will not be allowed to re-enter study.
Uncontrolled hypertension (systolic blood pressure \> 140 millimeters of mercury (mmHg) or diastolic pressure \> 90 mmHg despite optimal medical management)
Active or clinically significant cardiac disease including:
1. Congestive heart failure - New York Heart Association (NYHA) \> Class II
2. Active coronary artery disease
3. Cardiac arrhythmias requiring anti-arrhythmic therapy other than beta blockers or digoxin
4. Unstable angina (anginal symptoms at rest), new-onset angina within 3 months before randomization, or myocardial infarction within 6 months before randomization
Evidence or history of bleeding diathesis or coagulopathy, irrespective of severity
Any hemorrhage or bleeding event \> National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE) Grade 3 within 4 weeks prior to the start of study medication
Arterial or venous thrombotic or embolic events such as cerebrovascular accident (including transient ischemic attacks), deep vein thrombosis or pulmonary embolism within 6 month before the start of study medication (except for adequately treated catheter-related venous thrombosis occurring more than one month before the start of study medication)
Previously untreated or concurrent cancer that is distinct in primary site or histology from colorectal cancer except cervical cancer in-situ, treated basal cell carcinoma, or superficial bladder tumor. Patients surviving a cancer that was curatively treated and without evidence of disease for more than 3 years before randomization are allowed.All cancer treatments must be completed at least 3 years prior to study entry (i.e.,signature date of the ICF).
Clareo Health | A Phase 4 Study of Regorafenib in Metastatic Colorectal Cancer - Does Educating Physicians Change Patient Outcomes?
