Microdrilling Surgery for Full Thickness Chondral Lesions of the Knee Augmented With Concentrated Bone Marrow Aspirate, Platelet Rich Plasma and Hyaluronic Acid

NCT02285725•Joseph E. Broyles

Summary

This study seeks to evaluate a treatment for multiple full thickness chondral lesions in the knee. Eligible subjects will undergo a microdrilling surgery and up to 12 post operative intra-articular injections of bone marrow aspirate concentrate (BMAC), platelet rich plasma (PRP) and hyaluronic acid (HA).

Eligibility

Age

18 - 64 years

Sex

ALL

Healthy Volunteers

Exclusion Criteria

•Inflammatory arthritis
•Body mass index (BMI) greater than 35
•Presence of significant varus or valgus knee instability or unusually stiff knee
•Greater than 50% deviation of the mechanical axis
•Presence of active cardiac disease
•Presence of active pulmonary disease
•Prior septic arthritis of the involved joint
•Presence of active bacterial or Mycobacterial infection
•Presence of a known hypercoagulable state
•Pregnant or lactating females
+8 more criteria

Key Dates

Start Date

March 1, 2011

Primary Completion Date

February 15, 2019

Completion Date

February 15, 2019

Last Updated

July 27, 2023

Enrollment

ACTUAL participants

Conditions

Unilateral Primary Osteoarthritis of KneeOsteoarthritis KneeDegeneration; Articular Cartilage, KneeDegenerative Lesion of Articular Cartilage of Knee

Interventions

Microdrilling Surgery

PROCEDURE

Injections of BMAC + PRP + HA

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: July 27, 2023Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Microdrilling Surgery for Full Thickness Chondral Lesions of the Knee Augmented With Concentrated Bone Marrow Aspirate, Platelet Rich Plasma and Hyaluronic Acid

Exclusion Criteria

Orthobiologic Treatment for Knee Osteoarthritis

Impact of Blood Flow Restriction and Electrical Stimulation on Postoperative Muscle Atrophy and Pain After Total Knee Arthroplasty

Proprioception and BRACE Training in Knee Osteoarthritis

Effect of Biomechanical Correction in Medial Tibiofemoral Joint Osteoarthritis

The Synergistic Effects of Intra-articular Hyaluronic Acid and Platelet-rich Plasma Injections on Knee Osteoarthritis

the Safety and Efficacy Evaluation of Chondron Compared With Mircrofracture of Knee