Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Laval University
With
Canadian Institutes of Health Research (CIHR)
The investigators objective is to investigate the impact of COPD on key signaling pathways involved in the muscle atrophy. Moderate to severe COPD patients (FEV1 under 60% of predicted) and healthy controls will be recruited. All of the investigators patients will undergo a thorough baseline assessment in pulmonary capacity, muscle force and body composition. Blood sampling and biopsy of the quadriceps will be done. Key proteins of signaling intramuscular pathways involved in protein synthesis and degradation will be measured in the quadriceps.
Age
55–75
Sex
MALE
Healthy volunteers
Accepted
You may be eligible if
male
COPD with an FEV1 of under 60% of predicted
non-smoker
between 55 and 75 years old
You may not be if
all inflammatory disease (HIV, cancer, renal and cardiac deficiency)
hormonal dysregulation
inferior limb pathology
neuromuscular pathology
history of tobacco or alcool abuse
oxygen dependent
recent exacerbation (2 months) of the symptoms of COPD
